A synergistic blend of Cilantro (Coriandrum sativum), Ginkgo (Ginkgo biloba), Lemon Balm (Melissa officinalis), Biscuitroot (Lomatium dissectum), and St. John’s Wort (Hypericum perforatum). Key Five narrows BioPure's Viressence tincture down to five ingredients that bolster the body's natural immune defenses, detoxify, support the nervous system, and support microbial, parasitic and viral defense.
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Availability date: 07/3/2018
BioPure's herbal tinctures are each chosen for its specific health-supporting properties and strictly selected from the finest harvests. BioPure selects products grown in an environment free of fertilizers and insecticides. Our formulas are based on herbs with a proven historical track record in traditional healing therapies that have been used for centuries.
Inteded for internal or external use†.
Please Note: Not intended for use for children or during pregnancy or when breast feeding except under the care of a licensed medical practitioner.
Lemon balm is uniquely harmonizing in its effect on the human body. It can be used to calm anxiety, improve cognitive function, and be uplifting from depression (1,2). Its stress-relieving qualities have made it useful in treating hypertension, sleeplessness, nervous stomach (1), calming colicky infants (3), reducing agitation in Alzheimer’s patients (4), and improving mood disorders (1). In addition, Lemon Balm has been shown to have a high degree of antibacterial activity against gram-positive bacterial strains (5), as well as imparting antiviral action, especially in reducing the onset and severity of both genital and oral herpes outbreaks (6).
Research with St. John’s Wort has shown it to be at least as effective as many of the standard treatments for mild to moderate depression, with fewer side effects (7,8,9,10). It may be helpful in relieving symptoms of premenstrual syndrome, menopause, seasonal and other affective disorders (9,10,11,12), and in treating alcoholism (13). St John’s Wort also displays antibacterial and anti-inflammatory properties (14).
Biscuitroot is another Pacific Northwest native plant that was used by local Indian tribes for a variety of ailments, particularly respiratory tract disorders such as coughs, asthma, bronchitis, influenza, allergies, etc. Some reports attribute use of this herb in preventing fatalities among the Washoe Indians during the Spanish flu epidemic of 1918 (30).
Ginkgo biloba is most well known for its ability to enhance bloodflow, cognitive ability and memory (31,32,33). It contains two important classes of antioxidants; flavonoids and terpenoids. Flavonoids have anti-allergic, antiviral, antimicrobial, anti-inflammatory properties. The terpenoids in Ginkgo improve blood flow by relaxing blood vessels and reducing the stickiness of platelets, and may be helpful for patients with circulatory problems such as Raynauds Phenomenon (34,35).
The well-known culinary herb, Cilantro, contributes to the support of the immune system with dual antibacterial and antioxidant properties (39,40,41,42). Cilantro has also been shown to demonstrate antihyperglycaemic and insulin-like activity in diabetic mice (43), which contributes to the anti-diabetic action in Viressence.
(1) Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA and ScholeyAB. Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties. Neuropsychopharmacology (2003) 28, 1871–1881.
(2) Víctor López, Sara Martín, Maria Pilar Gómez-Serranillos, Maria Emilia Carretero, Anna K. Jäger and Maria Isabel Calvo. Neuroprotective and Neurological Properties of Melissa officinalis. Neurochemical Research. Volume 34, Number 11 (2009), 1955-1961.
(3) Savino F, Cresi F, Castagno E, Silvestro L, Oggero R. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil®) in the treatment of breastfed colicky infants. Phytotherapy Research. Volume 19, Issue 4, pages 335–340, April 2005.
(4) Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi A, and Khani M. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry. 2003 July; 74(7): 863–866.
(5) Hăncianu M, Aprotosoaie AC, Gille E, Poiată A, Tuchiluş C, Spac A, Stănescu U. Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania. Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):843-7.
(6) Wölbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine. Volume 1, Issue 1, June 1994, Pages 25–31.
(7) Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clin Ther. 2000 Apr;22(4):411-9.
(8) Whiskey E, Werneke U, Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. Int Clin Psychopharmacol. 2001 Sep;16(5):239-52.
(10)Mischoulon D. Update and critique of natural remedies as antidepressant treatments. Psychiatr Clin North Am. 2007 Mar;30(1):51-68.
(11)Martinez B, Kasper S, Ruhrmann S, Möller H-J. Hypericum in the Treatment of Seasonal Affective Disorders. J Geriatr Psychiatry Neurol. October 1994 vol. 7 no. 1 S29-S33.
(12)Harrer G. Hypericum and phototherapy. Praxis (Bern 1994). 2000 Dec 14;89(50):2123-9.
(13)Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, and Klein J. NMDA Receptor-Antagonistic Properties of Hyperforin, a Constituent of St. John’s Wort. J Pharmacol Sci 102, 47 – 54 (2006)
(14)Barnes J, Anderson LA, Phillipson JD. St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001 May;53(5):583-600.
(30)Bergner, P. Antiviral Botanicals in Herbal Medicine. Medical Herbalism (Spring 2005)14(3):1-12.
(32)Kennedy DO and Wightman EL. Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain Function. Adv. Nutr. 2: 32–50, 2011.
(33) Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. British Journal of Clinical Pharmacology. Volume 34, Issue 4, pages 352–358, Oct 1992.
(34)Nishida S, Satoh H. Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract. Clin Chim Acta. 2004 Jan;339(1-2):129-33.
(35)Muir AH, Robb R, McLaren M, Daly F, Belch JJ. The use of Ginkgo biloba in Raynaud's disease: a double-blind placebo-controlled trial. Vasc Med. 2002;7(4):265-7.
(39)Wong PYY, Kitts DD. Studies on the dual antioxidant and antibacterial properties of parsley (Petroselinum crispum) and cilantro (Coriandrum sativum) extracts. Food Chemistry. Volume 97, Issue 3, August 2006, Pages 505–515.
(40)L Joji Reddy, Reshma Devi Jalli, Beena Jose, Spandana Gopu. Evaluation of antibacterial and DPPH radical scavenging activities of the leaf extracts and leaf essential oil of Coriandrum sativum. World Journal of Pharmaceutical Research 2012. Vol 1, Issue 3, 705-716.
(41)Deepa B, Anuradha CV. Antioxidant potential of Coriandrum sativum L. seed extract. Indian J Exp Biol. 2011 Jan;49(1):30-8.
(42)M.S. Hashim, S. Lincy, V. Remya, M. Teena and L. Anila. Effect of polyphenolic compounds from Coriandrum sativum on H2O2-induced oxidative stress in human lymphocytes. Food Chemistry Volume 92, Issue 4, October 2005, Pages 653-660.
(43)Gray AM and Flatt PR. Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). British Journal of Nutrition / Volume 81 / Issue 3 / March 1999, pp 203-209.
† or use as directed by your healthcare practitioner.
* Our products are not intended to diagnose, treat, cure or prevent any disease and are designed to be used as part of an overall health plan with your authorized healthcare provider. Individuals taking food supplements or have an underlying health condition should consult with their authorized healthcare provider before using these products. We suggest that you consult your authorized healthcare provider if you have any health problems and require a medical diagnosis, medical advice or treatment. Statements herein have not been evaluated by the FDA. We do not recommend any of our natural products to be used for small children without the guidance of a licensed healthcare provider. We do not recommend that any of our products be used while breastfeeding, while pregnant or trying to become pregnant.
** Allergy test by using trace amount on skin and observing for 24 hours. Continue allergy test for consumption with trace amount and observe for 24 hours. Stop use of product if adverse reactions occur with ongoing use.
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